MAUDE: inferring expression changes in sorting-based CRISPR screens

Improved methods are needed to model CRISPR screen data for interrogation of genetic elements that alter reporter gene expression readout. We create MAUDE (Mean Alterations Using Discrete Expression) for quantifying the impact of guide RNAs on a target gene’s expression in a pooled, sorting-based ex...

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Detalles Bibliográficos
Autores principales: de Boer, Carl G., Ray, John P., Hacohen, Nir, Regev, Aviv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268349/
https://www.ncbi.nlm.nih.gov/pubmed/32493396
http://dx.doi.org/10.1186/s13059-020-02046-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268349/
https://www.ncbi.nlm.nih.gov/pubmed/32493396
http://dx.doi.org/10.1186/s13059-020-02046-8

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