Cargando…

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts

BACKGROUND: Previous studies indicate that soyasaponins may reduce inflammation via modulating toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling. However, its underlying mechanisms are still not fully understood. METHODS: Lipopolysaccharide (LPS)-challenged inflamed mal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Junbin, Ullah, Hidayat, Zheng, Zhongdaixi, Gu, Xiangfu, Su, Chuhong, Xiao, Lingyu, Wu, Xinglong, Xiong, Fei, Li, Qing, Zha, Longying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268359/ https://www.ncbi.nlm.nih.gov/pubmed/32493316 http://dx.doi.org/10.1186/s12906-020-2864-2

Ejemplares similares

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer
por: Block, Matthew S., et al.
Publicado: (2018)

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
por: Zheng, Chao, et al.
Publicado: (2020)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

MyD88 contribution to ocular surface homeostasis
por: Reins, Rose Y., et al.
Publicado: (2017)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

A Novel Kindred with MyD88 Deficiency
por: Bucciol, Giorgia, et al.
Publicado: (2022)

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2012)

From monogenic lupus to TLR7/MyD88-targeted therapy
por: Wang, Min, et al.
Publicado: (2022)

MyD88 Polymorphisms and Association with Susceptibility to Salmonella Pullorum
por: Liu, Xian-Qing, et al.
Publicado: (2015)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer
por: Silasi, Dan-Arin, et al.
Publicado: (2007)

Alternative activation of macrophages by filarial nematodes is MyD88-independent
por: Mylonas, Katie J., et al.
Publicado: (2013)

MyD88-Dependent Pathways in Leukocytes Affect the Retina in Diabetes
por: Tang, Jie, et al.
Publicado: (2013)

MyD88: a central player in innate immune signaling
por: Deguine, Jacques, et al.
Publicado: (2014)

MyD88 signalling is critical in the development of pancreatic cancer cachexia
por: Zhu, Xinxia, et al.
Publicado: (2019)

Possible Involvement of MyD88 in Regulating Stress Response in Mice
por: Hosoi, Toru, et al.
Publicado: (2021)

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice
por: Hosoi, Toru, et al.
Publicado: (2010)

Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers
por: Kim, Ki Hyung, et al.
Publicado: (2012)

TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells
por: Wu, Kunlin, et al.
Publicado: (2018)

TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease
por: Lee, Young-Kwan, et al.
Publicado: (2017)

Prognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells
por: Zhu, Yi, et al.
Publicado: (2012)

Mycobacterium tuberculosis Subverts the TLR-2 - MyD88 Pathway to Facilitate Its Translocation into the Cytosol
por: Rahman, Md. Aejazur, et al.
Publicado: (2014)

IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomas
por: Küppers, Ralf
Publicado: (2015)

Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways
por: Pang, Zheng, et al.
Publicado: (2018)

Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer’s pathology
por: Rangasamy, Suresh B., et al.
Publicado: (2018)

Enhanced Calvarial Bone Healing in CD11c-TLR4(−/−) and MyD88(−/−) Mice
por: Wang, Dan, et al.
Publicado: (2017)

The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer
por: Bates, Mark, et al.
Publicado: (2020)

Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils
por: Müller, Beate J., et al.
Publicado: (2021)

IL-1R–MyD88 signaling in keratinocyte transformation and carcinogenesis
por: Cataisson, Christophe, et al.
Publicado: (2012)

Ischemia-Reperfusion Lung Injury Is Attenuated in MyD88-Deficient Mice
por: Altemeier, William A., et al.
Publicado: (2013)

The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer
por: d'Adhemar, Charles J., et al.
Publicado: (2014)

Beyond MyD88 and TRIF Pathways in Toll-Like Receptor Signaling
por: Piras, Vincent, et al.
Publicado: (2014)

MyD88 promotes myoblast fusion in a cell-autonomous manner
por: Hindi, Sajedah M., et al.
Publicado: (2017)

Induction of Hypergammaglobulinemia and Autoantibodies by Salmonella Infection in MyD88-Deficient Mice
por: Issac, Jincy M., et al.
Publicado: (2018)

MyD88 Deficiency Protects Against Dry Eye–Induced Damage
por: Reins, Rose Y., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_esqh5p5vd1seevs3528kijtcgr