Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies

BACKGROUND: Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B(12). The introduction of a heterologous de novo vitamin B(12) biosynthesis pathway in Escherichia coli offers an alternative approach for its production. Although E. coli avoids major lim...

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Detalles Bibliográficos
Autores principales: Jiang, Pingtao, Fang, Huan, Zhao, Jing, Dong, Huina, Jin, Zhaoxia, Zhang, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268678/
https://www.ncbi.nlm.nih.gov/pubmed/32487216
http://dx.doi.org/10.1186/s12934-020-01377-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268678/
https://www.ncbi.nlm.nih.gov/pubmed/32487216
http://dx.doi.org/10.1186/s12934-020-01377-2

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