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Optimization of hydrogenobyrinic acid biosynthesis in Escherichia coli using multi-level metabolic engineering strategies

BACKGROUND: Hydrogenobyrinic acid is a key intermediate of the de-novo aerobic biosynthesis pathway of vitamin B(12). The introduction of a heterologous de novo vitamin B(12) biosynthesis pathway in Escherichia coli offers an alternative approach for its production. Although E. coli avoids major lim...

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Detalles Bibliográficos
Autores principales:	Jiang, Pingtao, Fang, Huan, Zhao, Jing, Dong, Huina, Jin, Zhaoxia, Zhang, Dawei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268678/ https://www.ncbi.nlm.nih.gov/pubmed/32487216 http://dx.doi.org/10.1186/s12934-020-01377-2

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