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Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity
BACKGROUND: Consecutive testing of single nucleotide polymorphisms (SNPs) is usually employed to identify genetic variants associated with complex traits. Ideally one should model all covariates in unison, but most existing analysis methods for genome-wide association studies (GWAS) perform only uni...
Autores principales: | Chu, Benjamin B, Keys, Kevin L, German, Christopher A, Zhou, Hua, Zhou, Jin J, Sobel, Eric M, Sinsheimer, Janet S, Lange, Kenneth |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268817/ https://www.ncbi.nlm.nih.gov/pubmed/32491161 http://dx.doi.org/10.1093/gigascience/giaa044 |
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