Lysophosphatidic acid reverses Temsirolimus-induced changes in lipid droplets and mitochondrial networks in renal cancer cells

Increased cytoplasmic lipid droplets (LDs) and elevated AKT/mTOR signaling are characteristics of clear cell renal cell carcinoma (ccRCC). Lysophosphatidic acid (LPA), a potent lipid mitogen generated via autotaxin (elevated in ccRCC), can modulate tumor progression but its role in altering chemothe...

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Detalles Bibliográficos
Autores principales: Chhabra, Ravneet, Nanjundan, Meera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269261/
https://www.ncbi.nlm.nih.gov/pubmed/32492043
http://dx.doi.org/10.1371/journal.pone.0233887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269261/
https://www.ncbi.nlm.nih.gov/pubmed/32492043
http://dx.doi.org/10.1371/journal.pone.0233887

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