Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus

Coronaviruses express a multifunctional papain-like protease, termed papain-like protease 2 (PLP2). PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiquitinating (DUB) enzyme which removes ubiquitin (Ub) moieties from ubiquitin-conjugated proteins. Previous in vitro...

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Detalles Bibliográficos
Autores principales: Deng, Xufang, Chen, Yafang, Mielech, Anna M., Hackbart, Matthew, Kesely, Kristina R., Mettelman, Robert C., O’Brien, Amornrat, Chapman, Mackenzie E., Mesecar, Andrew D., Baker, Susan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269429/
https://www.ncbi.nlm.nih.gov/pubmed/32188728
http://dx.doi.org/10.1128/JVI.01734-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269429/
https://www.ncbi.nlm.nih.gov/pubmed/32188728
http://dx.doi.org/10.1128/JVI.01734-19

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