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Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus

Coronaviruses express a multifunctional papain-like protease, termed papain-like protease 2 (PLP2). PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiquitinating (DUB) enzyme which removes ubiquitin (Ub) moieties from ubiquitin-conjugated proteins. Previous in vitro...

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Detalles Bibliográficos
Autores principales:	Deng, Xufang, Chen, Yafang, Mielech, Anna M., Hackbart, Matthew, Kesely, Kristina R., Mettelman, Robert C., O’Brien, Amornrat, Chapman, Mackenzie E., Mesecar, Andrew D., Baker, Susan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269429/ https://www.ncbi.nlm.nih.gov/pubmed/32188728 http://dx.doi.org/10.1128/JVI.01734-19

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