Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhi...

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Detalles Bibliográficos
Autores principales: Tsivkovski, Ruslan, Totrov, Maxim, Lomovskaya, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269513/
https://www.ncbi.nlm.nih.gov/pubmed/32152086
http://dx.doi.org/10.1128/AAC.00130-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269513/
https://www.ncbi.nlm.nih.gov/pubmed/32152086
http://dx.doi.org/10.1128/AAC.00130-20

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