Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer

BACKGROUND: Serine provides important precursors of protein, lipid, and nucleotide synthesis needed for tumor cell growth. Phosphoglycerate dehydrogenase (PHGDH), a key rate-limiting enzyme in the serine de novo synthesis pathway, is highly expressed in many tumor types (including gastric cancer) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaoya, Fu, Jianfei, Tang, Wanfen, Yu, Liangliang, Xu, Wenxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269635/
https://www.ncbi.nlm.nih.gov/pubmed/32581546
http://dx.doi.org/10.2147/OTT.S246430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269635/
https://www.ncbi.nlm.nih.gov/pubmed/32581546
http://dx.doi.org/10.2147/OTT.S246430

Ejemplares similares