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Inhibition of Serine Metabolism Promotes Resistance to Cisplatin in Gastric Cancer

BACKGROUND: Serine provides important precursors of protein, lipid, and nucleotide synthesis needed for tumor cell growth. Phosphoglycerate dehydrogenase (PHGDH), a key rate-limiting enzyme in the serine de novo synthesis pathway, is highly expressed in many tumor types (including gastric cancer) an...

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Detalles Bibliográficos
Autores principales:	Zhao, Xiaoya, Fu, Jianfei, Tang, Wanfen, Yu, Liangliang, Xu, Wenxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269635/ https://www.ncbi.nlm.nih.gov/pubmed/32581546 http://dx.doi.org/10.2147/OTT.S246430

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