Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway

Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by the dependence of their effects on the genetic background and environment. Even when molecular interactions between genes are known, it is unclear how these translate to organism-l...

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Detalles Bibliográficos
Autores principales: Kemble, Harry, Eisenhauer, Catherine, Couce, Alejandro, Chapron, Audrey, Magnan, Mélanie, Gautier, Gregory, Le Nagard, Hervé, Nghe, Philippe, Tenaillon, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269641/
https://www.ncbi.nlm.nih.gov/pubmed/32537514
http://dx.doi.org/10.1126/sciadv.abb2236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269641/
https://www.ncbi.nlm.nih.gov/pubmed/32537514
http://dx.doi.org/10.1126/sciadv.abb2236

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