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Flux, toxicity, and expression costs generate complex genetic interactions in a metabolic pathway
Our ability to predict the impact of mutations on traits relevant for disease and evolution remains severely limited by the dependence of their effects on the genetic background and environment. Even when molecular interactions between genes are known, it is unclear how these translate to organism-l...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269641/ https://www.ncbi.nlm.nih.gov/pubmed/32537514 http://dx.doi.org/10.1126/sciadv.abb2236 |