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Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion
Malaria parasites invade healthy red blood cells (RBCs) during the blood stage of the disease. Even though parasites initially adhere to RBCs with a random orientation, they need to align their apex toward the membrane in order to start the invasion process. Using hydrodynamic simulations of a RBC a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269671/ https://www.ncbi.nlm.nih.gov/pubmed/32420874 http://dx.doi.org/10.7554/eLife.56500 |
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author | Hillringhaus, Sebastian Dasanna, Anil K Gompper, Gerhard Fedosov, Dmitry A |
author_facet | Hillringhaus, Sebastian Dasanna, Anil K Gompper, Gerhard Fedosov, Dmitry A |
author_sort | Hillringhaus, Sebastian |
collection | PubMed |
description | Malaria parasites invade healthy red blood cells (RBCs) during the blood stage of the disease. Even though parasites initially adhere to RBCs with a random orientation, they need to align their apex toward the membrane in order to start the invasion process. Using hydrodynamic simulations of a RBC and parasite, where both interact through discrete stochastic bonds, we show that parasite alignment is governed by the combination of RBC membrane deformability and dynamics of adhesion bonds. The stochastic nature of bond-based interactions facilitates a diffusive-like re-orientation of the parasite at the RBC membrane, while RBC deformation aids in the establishment of apex-membrane contact through partial parasite wrapping by the membrane. This bond-based model for parasite adhesion quantitatively captures alignment times measured experimentally and demonstrates that alignment times increase drastically with increasing rigidity of the RBC membrane. Our results suggest that the alignment process is mediated simply by passive parasite adhesion. |
format | Online Article Text |
id | pubmed-7269671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-72696712020-06-05 Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion Hillringhaus, Sebastian Dasanna, Anil K Gompper, Gerhard Fedosov, Dmitry A eLife Physics of Living Systems Malaria parasites invade healthy red blood cells (RBCs) during the blood stage of the disease. Even though parasites initially adhere to RBCs with a random orientation, they need to align their apex toward the membrane in order to start the invasion process. Using hydrodynamic simulations of a RBC and parasite, where both interact through discrete stochastic bonds, we show that parasite alignment is governed by the combination of RBC membrane deformability and dynamics of adhesion bonds. The stochastic nature of bond-based interactions facilitates a diffusive-like re-orientation of the parasite at the RBC membrane, while RBC deformation aids in the establishment of apex-membrane contact through partial parasite wrapping by the membrane. This bond-based model for parasite adhesion quantitatively captures alignment times measured experimentally and demonstrates that alignment times increase drastically with increasing rigidity of the RBC membrane. Our results suggest that the alignment process is mediated simply by passive parasite adhesion. eLife Sciences Publications, Ltd 2020-05-18 /pmc/articles/PMC7269671/ /pubmed/32420874 http://dx.doi.org/10.7554/eLife.56500 Text en © 2020, Hillringhaus et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Physics of Living Systems Hillringhaus, Sebastian Dasanna, Anil K Gompper, Gerhard Fedosov, Dmitry A Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title | Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title_full | Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title_fullStr | Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title_full_unstemmed | Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title_short | Stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
title_sort | stochastic bond dynamics facilitates alignment of malaria parasite at erythrocyte membrane upon invasion |
topic | Physics of Living Systems |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269671/ https://www.ncbi.nlm.nih.gov/pubmed/32420874 http://dx.doi.org/10.7554/eLife.56500 |
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