Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently charac...

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Detalles Bibliográficos
Autores principales: Naser, Eyad, Kadow, Stephanie, Schumacher, Fabian, Mohamed, Zainelabdeen H., Kappe, Christian, Hessler, Gabriele, Pollmeier, Barbara, Kleuser, Burkhard, Arenz, Christoph, Becker, Katrin Anne, Gulbins, Erich, Carpinteiro, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269768/
https://www.ncbi.nlm.nih.gov/pubmed/32156719
http://dx.doi.org/10.1194/jlr.RA120000682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269768/
https://www.ncbi.nlm.nih.gov/pubmed/32156719
http://dx.doi.org/10.1194/jlr.RA120000682

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