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Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA editing enzyme Adar1 is required for fear extinction
DNA forms conformational states beyond the right-handed double-helix; however, the functional relevance of these non-canonical structures in the brain remains unknown. We show that, in the prefrontal cortex of mice, the formation of one such structure, Z-DNA, is involved in the regulation of extinct...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269834/ https://www.ncbi.nlm.nih.gov/pubmed/32367065 http://dx.doi.org/10.1038/s41593-020-0627-5 |