Cargando…
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA editing enzyme Adar1 is required for fear extinction
DNA forms conformational states beyond the right-handed double-helix; however, the functional relevance of these non-canonical structures in the brain remains unknown. We show that, in the prefrontal cortex of mice, the formation of one such structure, Z-DNA, is involved in the regulation of extinct...
Autores principales: | Marshall, Paul R., Zhao, Qiongyi, Li, Xiang, Wei, Wei, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Basic, Dean, Wang, Ziqi, Yin, Jiayu, Liau, Wei-Siang, Gupte, Ankita, Walkley, Carl R., Bredy, Timothy W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269834/ https://www.ncbi.nlm.nih.gov/pubmed/32367065 http://dx.doi.org/10.1038/s41593-020-0627-5 |
Ejemplares similares
-
ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3
por: Wei, Wei, et al.
Publicado: (2022) -
Fear extinction is regulated by the activity of long noncoding RNAs at the synapse
por: Liau, Wei-Siang, et al.
Publicado: (2023) -
The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
por: Li, Xiang, et al.
Publicado: (2019) -
Circular RNAs in the Brain: A Possible Role in
Memory?
por: Zajaczkowski, Esmi L., et al.
Publicado: (2020) -
Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
por: Heraud-Farlow, Jacki E., et al.
Publicado: (2017)