Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and RNA splicing and increased oligodendrocyte d...

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Detalles Bibliográficos
Autores principales: Wingo, Aliza P., Fan, Wen, Duong, Duc M., Gerasimov, Ekaterina S., Dammer, Eric B., Lu, Yue, Harerimana, Nadia V., White, Bartholomew, Thambisetty, Madhav, Troncoso, Juan C., Kim, Namhee, Schneider, Julie A., Hajjar, Ihab M., Lah, James J., Bennett, David A., Seyfried, Nicholas T., Levey, Allan I., Wingo, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269838/
https://www.ncbi.nlm.nih.gov/pubmed/32424284
http://dx.doi.org/10.1038/s41593-020-0635-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269838/
https://www.ncbi.nlm.nih.gov/pubmed/32424284
http://dx.doi.org/10.1038/s41593-020-0635-5

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