Cargando…

Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and RNA splicing and increased oligodendrocyte d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wingo, Aliza P., Fan, Wen, Duong, Duc M., Gerasimov, Ekaterina S., Dammer, Eric B., Lu, Yue, Harerimana, Nadia V., White, Bartholomew, Thambisetty, Madhav, Troncoso, Juan C., Kim, Namhee, Schneider, Julie A., Hajjar, Ihab M., Lah, James J., Bennett, David A., Seyfried, Nicholas T., Levey, Allan I., Wingo, Thomas S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269838/ https://www.ncbi.nlm.nih.gov/pubmed/32424284 http://dx.doi.org/10.1038/s41593-020-0635-5

Ejemplares similares

Sex differences in brain protein expression and disease
por: Wingo, Aliza P., et al.
Publicado: (2023)

A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3
por: Vattathil, Selina M., et al.
Publicado: (2021)

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2019)

Shared mechanisms across the major psychiatric and neurodegenerative diseases
por: Wingo, Thomas S., et al.
Publicado: (2022)

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
por: Johnson, Erik C. B., et al.
Publicado: (2018)

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis
por: Wingo, Aliza P., et al.
Publicado: (2021)

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21
por: Hales, Chadwick M, et al.
Publicado: (2014)

Effects of APOE Genotype on Brain Proteomic Network and Cell Type Changes in Alzheimer's Disease
por: Dai, Jingting, et al.
Publicado: (2018)

Brain proteome-wide association study implicates novel proteins in depression pathogenesis
por: Wingo, Thomas S., et al.
Publicado: (2021)

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
por: Dammer, Eric B., et al.
Publicado: (2023)

Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia
por: Wingo, Thomas S., et al.
Publicado: (2020)

Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder
por: Wingo, Thomas S., et al.
Publicado: (2022)

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level
por: Johnson, Erik C. B., et al.
Publicado: (2022)

Mitochondrial respiratory chain protein co-regulation in the human brain
por: Trumpff, Caroline, et al.
Publicado: (2022)

Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort
por: Christensen, Grace M., et al.
Publicado: (2023)

Brain microRNAs are associated with variation in cognitive trajectory in advanced age
por: Wingo, Aliza P., et al.
Publicado: (2022)

Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice
por: Mei, Zhen, et al.
Publicado: (2023)

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease
por: Modeste, Erica S., et al.
Publicado: (2023)

Differential DNA Methylation in the Brain as Potential Mediator of the Association between Traffic-related PM(2.5) and Neuropathology Markers of Alzheimer’s Disease
por: Li, Zhenjiang, et al.
Publicado: (2023)

Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease
por: Donovan, Laura E, et al.
Publicado: (2013)

Correction to: Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer’s disease
por: Donovan, Laura E., et al.
Publicado: (2021)

LDL cholesterol is associated with higher AD neuropathology burden independent of APOE
por: Wingo, Aliza P, et al.
Publicado: (2022)

Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer’s Disease
por: Higginbotham, Lenora, et al.
Publicado: (2019)

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome
por: Dammer, Eric B., et al.
Publicado: (2022)

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
por: Higginbotham, Lenora, et al.
Publicado: (2020)

Predictors of Cognitive Decline in Healthy Middle-Aged Individuals with Asymptomatic Alzheimer’s Disease
por: Tandon, Raghav, et al.
Publicado: (2023)

Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes—Activation and Age-Related Effects
por: Rangaraju, Srikant, et al.
Publicado: (2018)

A proteomic network approach across the ALS‐FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain
por: Umoh, Mfon E, et al.
Publicado: (2017)

Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s disease
por: Zhou, Maotian, et al.
Publicado: (2020)

APOE expression and secretion are modulated by mitochondrial dysfunction
por: Wynne, Meghan E, et al.
Publicado: (2023)

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
por: Swarup, Vivek, et al.
Publicado: (2020)

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination
por: Dammer, Eric B., et al.
Publicado: (2012)

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease
por: Ping, Lingyan, et al.
Publicado: (2018)

Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease
por: Gockley, Jake, et al.
Publicado: (2021)

Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue
por: Ma, Yiyi, et al.
Publicado: (2021)

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
por: Rangaraju, Srikant, et al.
Publicado: (2017)

TBK1 interacts with tau and enhances neurodegeneration in tauopathy
por: Abreha, Measho H., et al.
Publicado: (2021)

A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer’s disease
por: Huang, Yanting, et al.
Publicado: (2021)

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins
por: Rangaraju, Srikant, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6mtk3gpb596q83m7jcbt3o68dk