Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide

Temozolomide (TMZ) insensitivity and resistance are major causes of treatment failure and poor prognosis for GBM patients. Here, we identify LRRC4 as a novel autophagy inhibitor that restores the sensitivity of GBMs to TMZ. LRRC4 was associated with the DEPTOR/mTOR complex, and this interaction resu...

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Detalles Bibliográficos
Autores principales: Feng, Jianbo, Zhang, Yan, Ren, Xing, Li, Di, Fu, Haijuan, Liu, Changhong, Zhou, Wen, Liu, Qing, Liu, Qiang, Wu, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269909/
https://www.ncbi.nlm.nih.gov/pubmed/32372061
http://dx.doi.org/10.1038/s41388-020-1312-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269909/
https://www.ncbi.nlm.nih.gov/pubmed/32372061
http://dx.doi.org/10.1038/s41388-020-1312-6

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