Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved through incorporation of target sites (TSs) for miR...

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Detalles Bibliográficos
Autores principales: Kraszewska, Izabela, Tomczyk, Mateusz, Andrysiak, Kalina, Biniecka, Monika, Geisler, Anja, Fechner, Henry, Zembala, Michał, Stępniewski, Jacek, Dulak, Józef, Jaźwa-Kusior, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270145/
https://www.ncbi.nlm.nih.gov/pubmed/32518806
http://dx.doi.org/10.1016/j.omtm.2020.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270145/
https://www.ncbi.nlm.nih.gov/pubmed/32518806
http://dx.doi.org/10.1016/j.omtm.2020.05.006

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