Reduced Heterochromatin Formation on the pFAR4 Miniplasmid Allows Sustained Transgene Expression in the Mouse Liver

Non-viral gene delivery into the liver generally mediates a transient transgene expression. A comparative analysis was performed using two gene vectors, pFAR4 and pKAR4, which differ by the absence or presence of an antibiotic resistance marker, respectively. Both plasmids carried the same eukaryoti...

Descripción completa

Detalles Bibliográficos
Autores principales: Pastor, Marie, Quiviger, Mickäel, Pailloux, Julie, Scherman, Daniel, Marie, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270507/
https://www.ncbi.nlm.nih.gov/pubmed/32505001
http://dx.doi.org/10.1016/j.omtn.2020.05.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270507/
https://www.ncbi.nlm.nih.gov/pubmed/32505001
http://dx.doi.org/10.1016/j.omtn.2020.05.014

Ejemplares similares