AP‐2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons

Cleavage of amyloid precursor protein (APP) by BACE‐1 (β‐site APP cleaving enzyme 1) is the rate‐limiting step in amyloid‐β (Aβ) production and a neuropathological hallmark of Alzheimer's disease (AD). Despite decades of research, mechanisms of amyloidogenic APP processing remain highly controv...

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Detalles Bibliográficos
Autores principales: Bera, Sujoy, Camblor‐Perujo, Santiago, Calleja Barca, Elena, Negrete‐Hurtado, Albert, Racho, Julia, De Bruyckere, Elodie, Wittich, Christoph, Ellrich, Nina, Martins, Soraia, Adjaye, James, Kononenko, Natalia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271323/
https://www.ncbi.nlm.nih.gov/pubmed/32323475
http://dx.doi.org/10.15252/embr.201947954

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271323/
https://www.ncbi.nlm.nih.gov/pubmed/32323475
http://dx.doi.org/10.15252/embr.201947954

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