The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity

The Disrupted in schizophrenia 1 (DISC1) gene encodes a scaffolding protein that is involved in many neural functions such as neurogenesis, neural differentiation, embryonic neuron migration and neurotransmitter signalling. DISC1 was originally implicated in schizophrenia in a single family with a d...

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Detalles Bibliográficos
Autores principales: Su, Ping, Zhang, Hailong, Wong, Albert H. C., Liu, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271519/
https://www.ncbi.nlm.nih.gov/pubmed/32493513
http://dx.doi.org/10.1186/s13041-020-00625-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271519/
https://www.ncbi.nlm.nih.gov/pubmed/32493513
http://dx.doi.org/10.1186/s13041-020-00625-1

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