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The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity
The Disrupted in schizophrenia 1 (DISC1) gene encodes a scaffolding protein that is involved in many neural functions such as neurogenesis, neural differentiation, embryonic neuron migration and neurotransmitter signalling. DISC1 was originally implicated in schizophrenia in a single family with a d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271519/ https://www.ncbi.nlm.nih.gov/pubmed/32493513 http://dx.doi.org/10.1186/s13041-020-00625-1 |