Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography

BACKGROUND: Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in...

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Autores principales: Rommel, Felix, Rothe, Matthias, Kurz, Maximilian, Prasuhn, Michelle, Grisanti, Salvatore, Ranjbar, Mahdy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271533/
https://www.ncbi.nlm.nih.gov/pubmed/32518691
http://dx.doi.org/10.1186/s40942-020-00227-y
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author Rommel, Felix
Rothe, Matthias
Kurz, Maximilian
Prasuhn, Michelle
Grisanti, Salvatore
Ranjbar, Mahdy
author_facet Rommel, Felix
Rothe, Matthias
Kurz, Maximilian
Prasuhn, Michelle
Grisanti, Salvatore
Ranjbar, Mahdy
author_sort Rommel, Felix
collection PubMed
description BACKGROUND: Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in the afternoon. In this index study, OCTA was used to investigate diurnal changes of the retinal perfusion in healthy adult eyes and to identify impacting factors since retinal perfusion is known to be mainly determined by autoregulatory mechanisms. METHODS: A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of mean arterial pressure (MAP), intraocular pressure (IOP), macular volume (MV), subfoveal choroidal thickness (SFCT), foveal avascular zone (FAZ) and retinal perfusion of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and full retina (FR) slab at 7 a.m. and 4 p.m. Possible influence of MAP or IOP on the retinal perfusion was evaluated. RESULTS: A total of 22 eyes of 22 participants (mean age 55.91 ± 14.84) were analysed. Significant diurnal changes from 7 a.m. to 4 p.m. were observed for MAP (p < 0.001) and SFCT (p = 0.017). The perfusion of SCP, DCP and FR as well as the size of the FAZ and the MV did not show significant fluctuation during the day. No significant correlation between MAP or IOP and retinal perfusion values were detectable. CONCLUSION: OCTA-based analysis of the retina in healthy adults demonstrated a steady perfusion of both plexus during the day, independently of changes in MAP. These findings support the theory of autoregulatory mechanisms of the retinal blood flow.
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spelling pubmed-72715332020-06-08 Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography Rommel, Felix Rothe, Matthias Kurz, Maximilian Prasuhn, Michelle Grisanti, Salvatore Ranjbar, Mahdy Int J Retina Vitreous Original Article BACKGROUND: Optical coherence tomography angiography (OCTA) is a non-invasive tool for imaging and quantifying the retinal and choroidal vasculature as well as perfusion state in healthy eyes. Choroidal perfusion is subject to diurnal variation, showing lowest perfusion in the morning and highest in the afternoon. In this index study, OCTA was used to investigate diurnal changes of the retinal perfusion in healthy adult eyes and to identify impacting factors since retinal perfusion is known to be mainly determined by autoregulatory mechanisms. METHODS: A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of mean arterial pressure (MAP), intraocular pressure (IOP), macular volume (MV), subfoveal choroidal thickness (SFCT), foveal avascular zone (FAZ) and retinal perfusion of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and full retina (FR) slab at 7 a.m. and 4 p.m. Possible influence of MAP or IOP on the retinal perfusion was evaluated. RESULTS: A total of 22 eyes of 22 participants (mean age 55.91 ± 14.84) were analysed. Significant diurnal changes from 7 a.m. to 4 p.m. were observed for MAP (p < 0.001) and SFCT (p = 0.017). The perfusion of SCP, DCP and FR as well as the size of the FAZ and the MV did not show significant fluctuation during the day. No significant correlation between MAP or IOP and retinal perfusion values were detectable. CONCLUSION: OCTA-based analysis of the retina in healthy adults demonstrated a steady perfusion of both plexus during the day, independently of changes in MAP. These findings support the theory of autoregulatory mechanisms of the retinal blood flow. BioMed Central 2020-06-03 /pmc/articles/PMC7271533/ /pubmed/32518691 http://dx.doi.org/10.1186/s40942-020-00227-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Article
Rommel, Felix
Rothe, Matthias
Kurz, Maximilian
Prasuhn, Michelle
Grisanti, Salvatore
Ranjbar, Mahdy
Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title_full Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title_fullStr Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title_full_unstemmed Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title_short Evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
title_sort evaluating diurnal variations in retinal perfusion using optical coherence tomography angiography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271533/
https://www.ncbi.nlm.nih.gov/pubmed/32518691
http://dx.doi.org/10.1186/s40942-020-00227-y
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