Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types

Innate drug sensitivity in healthy cells aids identification of lineage specific anti-cancer therapies and reveals off-target effects. To characterize the diversity in drug responses in the major hematopoietic cell types, we simultaneously assessed their sensitivity to 71 small molecules utilizing a...

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Detalles Bibliográficos
Autores principales: Majumder, Muntasir M., Leppä, Aino-Maija, Hellesøy, Monica, Dowling, Paul, Malyutina, Alina, Kopperud, Reidun, Bazou, Despina, Andersson, Emma, Parsons, Alun, Tang, Jing, Kallioniemi, Olli, Mustjoki, Satu, O’Gorman, Peter, Wennerberg, Krister, Porkka, Kimmo, Gjertsen, Bjørn T., Heckman, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271564/
https://www.ncbi.nlm.nih.gov/pubmed/31439679
http://dx.doi.org/10.3324/haematol.2019.217414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271564/
https://www.ncbi.nlm.nih.gov/pubmed/31439679
http://dx.doi.org/10.3324/haematol.2019.217414

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