Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids

Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs. While urinary excretion is the primary elimination route of enala...

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Detalles Bibliográficos
Autores principales: Ni, Yao, Duan, Zelin, Zhou, Dandan, Liu, Shuai, Wan, Huida, Gui, Chunshan, Zhang, Hongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271668/
https://www.ncbi.nlm.nih.gov/pubmed/32547398
http://dx.doi.org/10.3389/fphar.2020.00802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271668/
https://www.ncbi.nlm.nih.gov/pubmed/32547398
http://dx.doi.org/10.3389/fphar.2020.00802

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