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siRNA inhibition and not chemical inhibition of Suv39h1/2 enhances pre-implantation embryonic development of bovine somatic cell nuclear transfer embryos
The efficiency of somatic cell nuclear transfer (SCNT) is low due to the strong resistance of somatic donor cells to epigenetic reprogramming. Many epigenetic drugs targeting DNA methylation and histone acetylation have been used in attempts to improve the in vitro and in vivo development of SCNT em...
Autores principales: | Jafarpour, Farnoosh, Ghazvini Zadegan, Faezeh, Ostadhosseini, Somayyeh, Hajian, Mehdi, Kiani-Esfahani, Abbas, Nasr-Esfahani, M. H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272017/ https://www.ncbi.nlm.nih.gov/pubmed/32497112 http://dx.doi.org/10.1371/journal.pone.0233880 |
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