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S100A1 blocks the interaction between p53 and mdm2 and decreases cell proliferation activity
About 50% of human cancers across the globe arise due to a mutation in the p53 gene which gives rise to its functional inactive form, and in the rest of the cancer the efficacy of active p53 (wild-type) is hindered by MDM2-mediated degradation. Breakdown of the p53-MDM2 association may constitute an...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272100/ https://www.ncbi.nlm.nih.gov/pubmed/32497081 http://dx.doi.org/10.1371/journal.pone.0234152 |