Evaluating drug targets through human loss-of-function genetic variation

Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets us...

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Detalles Bibliográficos
Autores principales: Minikel, Eric Vallabh, Karczewski, Konrad J., Martin, Hilary C., Cummings, Beryl B., Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C., van Heel, David A., Daly, Mark J., Schreiber, Stuart L., MacArthur, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272226/
https://www.ncbi.nlm.nih.gov/pubmed/32461653
http://dx.doi.org/10.1038/s41586-020-2267-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272226/
https://www.ncbi.nlm.nih.gov/pubmed/32461653
http://dx.doi.org/10.1038/s41586-020-2267-z

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