Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a severe and heterogeneous disease that lacks an approved targeted therapy and has a poor clinical outcome to chemotherapy. Although the RAS-ERK signaling axis is rarely mutated in TNBC, ~50% of TNBCs show an increased copy number and overexpression of epiderm...

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Detalles Bibliográficos
Autores principales: Ryu, Won-Ji, Lee, Jeong Dong, Park, Jong-Chan, Cha, Pu-Hyeon, Cho, Yong-Hee, Kim, Jee Ye, Sohn, Joo Hyuk, Paik, Soonmyung, Choi, Kang-Yell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272395/
https://www.ncbi.nlm.nih.gov/pubmed/32457491
http://dx.doi.org/10.1038/s12276-020-0440-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272395/
https://www.ncbi.nlm.nih.gov/pubmed/32457491
http://dx.doi.org/10.1038/s12276-020-0440-y

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