Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone and non-aggregation prone intermediates, but identifying these within the dynamic ensemble of monomeric conformations is difficult. Herein,...

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Detalles Bibliográficos
Autores principales: Stephens, Amberley D., Zacharopoulou, Maria, Moons, Rani, Fusco, Giuliana, Seetaloo, Neeleema, Chiki, Anass, Woodhams, Philippa J., Mela, Ioanna, Lashuel, Hilal A., Phillips, Jonathan J., De Simone, Alfonso, Sobott, Frank, Schierle, Gabriele S. Kaminski
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272411/
https://www.ncbi.nlm.nih.gov/pubmed/32499486
http://dx.doi.org/10.1038/s41467-020-16564-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272411/
https://www.ncbi.nlm.nih.gov/pubmed/32499486
http://dx.doi.org/10.1038/s41467-020-16564-3

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