Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling

K-Ras must interact primarily with the plasma membrane (PM) for its biological activity. Therefore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we found that avicin G, a family of natural plant-derived triterpenoid saponins from Acacia victoriae,...

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Detalles Bibliográficos
Autores principales: Garrido, Christian M., Henkels, Karen M., Rehl, Kristen M., Liang, Hong, Zhou, Yong, Gutterman, Jordan U., Cho, Kwang-jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272413/
https://www.ncbi.nlm.nih.gov/pubmed/32499517
http://dx.doi.org/10.1038/s41598-020-65882-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272413/
https://www.ncbi.nlm.nih.gov/pubmed/32499517
http://dx.doi.org/10.1038/s41598-020-65882-5

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