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Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling
K-Ras must interact primarily with the plasma membrane (PM) for its biological activity. Therefore, disrupting K-Ras PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we found that avicin G, a family of natural plant-derived triterpenoid saponins from Acacia victoriae,...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272413/ https://www.ncbi.nlm.nih.gov/pubmed/32499517 http://dx.doi.org/10.1038/s41598-020-65882-5 |