Cargando…

A novel, rationally designed, hybrid antimicrobial peptide, inspired by cathelicidin and aurein, exhibits membrane-active mechanisms against Pseudomonas aeruginosa

Antimicrobial peptides (AMPs) are promising alternatives to classical antibiotics for the treatment of drug-resistant infections. Due to their versatility and unlimited sequence space, AMPs can be rationally designed by modulating physicochemical determinants to favor desired biological parameters a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klubthawee, Natthaporn, Adisakwattana, Poom, Hanpithakpong, Warunee, Somsri, Sangdao, Aunpad, Ratchaneewan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272617/ https://www.ncbi.nlm.nih.gov/pubmed/32499514 http://dx.doi.org/10.1038/s41598-020-65688-5

Ejemplares similares

A Mitochondria-Penetrating Peptide Exerts Potent Anti-Plasmodium Activity and Localizes at Parasites’ Mitochondria
por: Somsri, Sangdao, et al.
Publicado: (2021)

A Thermostable, Modified Cathelicidin-Derived Peptide With Enhanced Membrane-Active Activity Against Salmonella enterica serovar Typhimurium
por: Klubthawee, Natthaporn, et al.
Publicado: (2021)

The effect of mimicking febrile temperature and drug stress on malarial development
por: Aunpad, Ratchaneewan, et al.
Publicado: (2009)

A novel designed membrane-active peptide for the control of foodborne Salmonella enterica serovar Typhimurium
por: Sengkhui, Siriwan, et al.
Publicado: (2023)

Novel D-form of hybrid peptide (D-AP19) rapidly kills Acinetobacter baumannii while tolerating proteolytic enzymes
por: Jariyarattanarach, Phanvimon, et al.
Publicado: (2022)

Author Correction: Novel D-form of hybrid peptide (D-AP19) rapidly kills Acinetobacter baumannii while tolerating proteolytic enzymes
por: Jariyarattanarach, Phanvimon, et al.
Publicado: (2023)

Structural and biological features of a novel plant defensin from Brugmansia x candida
por: Kaewklom, Siriporn, et al.
Publicado: (2018)

Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2
por: de Freitas, Laura Marise, et al.
Publicado: (2018)

Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2
por: Migoń, Dorian, et al.
Publicado: (2018)

Interaction of the Antimicrobial Peptide Aurein 1.2 and Charged Lipid Bilayer
por: Rai, Durgesh K., et al.
Publicado: (2017)

Cathelicidin-inspired antimicrobial peptides as novel antifungal compounds
por: van Eijk, Martin, et al.
Publicado: (2020)

Enzymatic characterization and structure-function relationship of two chitinases, LmChiA and LmChiB, from Listeria monocytogenes
por: Churklam, Wasinee, et al.
Publicado: (2020)

Cathelicidin-Derived Synthetic Peptide Improves Therapeutic Potential of Vancomycin Against Pseudomonas aeruginosa
por: Mohammed, Imran, et al.
Publicado: (2019)

Controls and constrains of the membrane disrupting action of Aurein 1.2
por: Shahmiri, Mahdi, et al.
Publicado: (2015)

Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo
por: Coorens, Maarten, et al.
Publicado: (2017)

Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides
por: Zheng, Mengjun, et al.
Publicado: (2021)

Colicin type 7 produced by majority of Shigella sonnei isolated from Thai patients with diarrhoea
por: Kaewklom, Siriporn, et al.
Publicado: (2014)

Palm Kernel Meal Protein Hydrolysates Enhance Post-Thawed Boar Sperm Quality
por: Khophloiklang, Vassakorn, et al.
Publicado: (2023)

Systemic Responses of Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Following Exposure to the Antimicrobial Peptide Cathelicidin-BF Imply Multiple Intracellular Targets
por: Liu, Cunbao, et al.
Publicado: (2017)

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo
por: Beaumont, Paula E., et al.
Publicado: (2014)

Could Cardiolipin Protect Membranes against the Action of Certain Antimicrobial Peptides? Aurein 1.2, a Case Study
por: Poger, David, et al.
Publicado: (2018)

Cathelicidins: Immunomodulatory Antimicrobials
por: van Harten, Roel M., et al.
Publicado: (2018)

Mixed Communities of Mucoid and Nonmucoid Pseudomonas aeruginosa Exhibit Enhanced Resistance to Host Antimicrobials
por: Malhotra, Sankalp, et al.
Publicado: (2018)

Effective inhibition of Clostridioides difficile by the novel peptide CM-A
por: Arthithanyaroj, Sirirak, et al.
Publicado: (2021)

Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities
por: Manzo, Giorgia, et al.
Publicado: (2019)

Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD
por: Shelton, Catherine L., et al.
Publicado: (2022)

Responses of Pseudomonas aeruginosa to antimicrobials
por: Morita, Yuji, et al.
Publicado: (2014)

A Novel Strategy for the Design of Aurein 1.2 Analogs with Enhanced Bioactivities by Conjunction of Cell-Penetrating Regions
por: Liao, Fengting, et al.
Publicado: (2023)

Designing Potent Anticancer Peptides by Aurein 1.2 Key Residues Mutation and Catenate Cell-Penetrating Peptide
por: Salarpour Garnaie, Hamta, et al.
Publicado: (2023)

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa
por: McHugh, Brian J., et al.
Publicado: (2019)

Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins
por: Bolosov, Ilia A., et al.
Publicado: (2021)

Imaging the antimicrobial mechanism(s) of cathelicidin-2
por: Schneider, Viktoria A. F., et al.
Publicado: (2016)

Surface-Growing Communities of Pseudomonas aeruginosa Exhibit Distinct Alkyl Quinolone Signatures
por: Morales-Soto, Nydia, et al.
Publicado: (2018)

Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus
por: Cho, Hye-sun, et al.
Publicado: (2020)

Core–shell magnetic nanoparticles display synergistic antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus when combined with cathelicidin LL-37 or selected ceragenins
por: Niemirowicz, Katarzyna, et al.
Publicado: (2016)

Two Homologous EF-G Proteins from Pseudomonas aeruginosa Exhibit Distinct Functions
por: Palmer, Stephanie O., et al.
Publicado: (2013)

Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model
por: Kumar, Manoj, et al.
Publicado: (2021)

Cefiderocol Activity Against Clinical Pseudomonas aeruginosa Isolates Exhibiting Ceftolozane-Tazobactam Resistance
por: Simner, Patricia J, et al.
Publicado: (2021)

Isolation of a bacteriophage targeting Pseudomonas aeruginosa and exhibits a promising in vivo efficacy
por: Abdelghafar, Aliaa, et al.
Publicado: (2023)

Cathelicidins: family of antimicrobial peptides. A review
por: Kościuczuk, Ewa M., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_2a5ipca6sb5od9voge2vvl4ilc