Cargando…
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells meet the biological requirement for spatiotemporal regulation of cellular components and reactions. Recently, tau, a protein known for its involvement in Alzheimer’s disease and other tauopathies, was found to...
Autores principales: | Kanaan, Nicholas M., Hamel, Chelsey, Grabinski, Tessa, Combs, Benjamin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272632/ https://www.ncbi.nlm.nih.gov/pubmed/32499559 http://dx.doi.org/10.1038/s41467-020-16580-3 |
Ejemplares similares
-
EFhd2 Affects Tau Liquid–Liquid Phase Separation
por: Vega, Irving E., et al.
Publicado: (2019) -
Pathological conformations involving the amino terminus of tau occur early in Alzheimer’s disease and are differentially detected by monoclonal antibodies
por: Combs, Benjamin, et al.
Publicado: (2016) -
Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope
por: Kang, Sang-Gyun, et al.
Publicado: (2021) -
Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey
por: Kanaan, Nicholas M., et al.
Publicado: (2021) -
Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)