A Novel MFS-MDR Transporter, MdrP, Employs D223 as a Key Determinant in the Na(+) Translocation Coupled to Norfloxacin Efflux

Multidrug resistance (MDR) transporters of the major facilitator superfamily (MFS) were previously believed to drive the extrusion of multiple antimicrobial drugs through the coupling to proton translocation. Here, we present the identification of the first Na(+)-coupled MFS-MDR transporter, MdrP, w...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Abdel-Motaal, Heba, Zou, Qiao, Guo, Sijia, Zheng, Xiutao, Wang, Yuting, Zhang, Zhenglai, Meng, Lin, Xu, Tong, Jiang, Juquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272687/
https://www.ncbi.nlm.nih.gov/pubmed/32547505
http://dx.doi.org/10.3389/fmicb.2020.00955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272687/
https://www.ncbi.nlm.nih.gov/pubmed/32547505
http://dx.doi.org/10.3389/fmicb.2020.00955

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