Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the absence of the autophagic machinery, nuclear protein aggregates require a solubilization step preceding degradation by...

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Detalles Bibliográficos
Autores principales: den Brave, Fabian, Cairo, Lucas V., Jagadeesan, Chandhuru, Ruger-Herreros, Carmen, Mogk, Axel, Bukau, Bernd, Jentsch, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273177/
https://www.ncbi.nlm.nih.gov/pubmed/32492414
http://dx.doi.org/10.1016/j.celrep.2020.107680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273177/
https://www.ncbi.nlm.nih.gov/pubmed/32492414
http://dx.doi.org/10.1016/j.celrep.2020.107680

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