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Truncation of C-Terminal Intrinsically Disordered Region of Mycobacterial Rv1915 Facilitates Production of “Difficult-to-Purify” Recombinant Drug Target

Availability of purified drug target is a prerequisite for its structural and functional characterization. However, aggregation of recombinant protein as inclusion bodies (IBs) is a common problem during the large scale production of overexpressed protein in heterologous host. Such proteins can be r...

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Detalles Bibliográficos
Autores principales: Antil, Monika, Gouin, Sébastien G., Gupta, Vibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273500/
https://www.ncbi.nlm.nih.gov/pubmed/32548107
http://dx.doi.org/10.3389/fbioe.2020.00522