Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscor...

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Detalles Bibliográficos
Autores principales: Taylor, Gregory A., Huang, Hsin-I, Fee, Brian E., Youssef, Nourhan, Jewell, Mark L., Cantillana, Viviana, Schoenborn, Alexi A., Rogala, Allison R., Buckley, Anne F., Feng, Carl G., Vallance, Bruce A., Gulati, Ajay S., Hammer, Gianna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274479/
https://www.ncbi.nlm.nih.gov/pubmed/32453761
http://dx.doi.org/10.1371/journal.ppat.1008553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274479/
https://www.ncbi.nlm.nih.gov/pubmed/32453761
http://dx.doi.org/10.1371/journal.ppat.1008553

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