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Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In order to understand whether and how lysosomes alter with age and contribute to lifespan regulation, we characterized multiple properties of lysosomes during the aging process in C. elegans. We uncovered age-depen...

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Detalles Bibliográficos
Autores principales: Sun, Yanan, Li, Meijiao, Zhao, Dongfeng, Li, Xin, Yang, Chonglin, Wang, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274789/
https://www.ncbi.nlm.nih.gov/pubmed/32482227
http://dx.doi.org/10.7554/eLife.55745