MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

The MYC oncogene drives T- and B- lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Here, we demonstrate a systemic reduction in natural killer (NK) cell numbers in SRα-tTA/Tet-O-MYC(ON) mice bearing MYC-driven T-lymphomas. Residual mNK cells in spleens...

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Detalles Bibliográficos
Autores principales: Swaminathan, Srividya, Hansen, Aida S., Heftdal, Line D., Dhanasekaran, Renumathy, Deutzmann, Anja, Fernandez, Wadie D. M., Liefwalker, Daniel F., Horton, Crista, Mosley, Adriane, Liebersbach, Mariola, Maecker, Holden T., Felsher, Dean W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275060/
https://www.ncbi.nlm.nih.gov/pubmed/32503978
http://dx.doi.org/10.1038/s41467-020-16447-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275060/
https://www.ncbi.nlm.nih.gov/pubmed/32503978
http://dx.doi.org/10.1038/s41467-020-16447-7

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