Cargando…

MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

The MYC oncogene drives T- and B- lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Here, we demonstrate a systemic reduction in natural killer (NK) cell numbers in SRα-tTA/Tet-O-MYC(ON) mice bearing MYC-driven T-lymphomas. Residual mNK cells in spleens...

Descripción completa

Detalles Bibliográficos
Autores principales:	Swaminathan, Srividya, Hansen, Aida S., Heftdal, Line D., Dhanasekaran, Renumathy, Deutzmann, Anja, Fernandez, Wadie D. M., Liefwalker, Daniel F., Horton, Crista, Mosley, Adriane, Liebersbach, Mariola, Maecker, Holden T., Felsher, Dean W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275060/ https://www.ncbi.nlm.nih.gov/pubmed/32503978 http://dx.doi.org/10.1038/s41467-020-16447-7

Ejemplares similares

Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma
por: Lai, Ian, et al.
Publicado: (2018)

Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies
por: Liefwalker, Daniel F., et al.
Publicado: (2021)

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)
por: Dhanasekaran, Renumathy, et al.
Publicado: (2017)

A mathematical model of tumor regression and recurrence after therapeutic oncogene inactivation
por: Hori, Sharon S., et al.
Publicado: (2021)

MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint
por: Smith, Benjamin A. H., et al.
Publicado: (2023)

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt’s lymphoma
por: Poole, Candace J., et al.
Publicado: (2017)

MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC
por: Dhanasekaran, Renumathy, et al.
Publicado: (2020)

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity
por: Dhanasekaran, Renumathy, et al.
Publicado: (2020)

PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals
por: Cohn, Gabriel M., et al.
Publicado: (2020)

BIM-mediated apoptosis and oncogene addiction
por: Li, Yulin, et al.
Publicado: (2016)

Current and Emerging Tools for Hepatocellular Carcinoma Surveillance
por: Adeniji, Nia, et al.
Publicado: (2021)

Metabolic vulnerabilities of MYC-induced cancer
por: Gouw, Arvin M., et al.
Publicado: (2016)

Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
por: Dhanasekaran, Renumathy, et al.
Publicado: (2012)

Chinese Skullcap in Move Free Arthritis Supplement Causes Drug Induced Liver Injury and Pulmonary Infiltrates
por: Dhanasekaran, Renumathy, et al.
Publicado: (2013)

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia
por: Duault, Caroline, et al.
Publicado: (2021)

Elevated myc expression and c-myc amplification in spontaneously occurring B lymphoid cell lines
Publicado: (1987)

Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances
por: Dhanasekaran, Renumathy, et al.
Publicado: (2016)

BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia
por: Li, Yulin, et al.
Publicado: (2016)

Rare Case of Adult Undifferentiated (Embryonal) Sarcoma of the Liver Treated with Liver Transplantation: Excellent Long-Term Survival
por: Dhanasekaran, Renumathy, et al.
Publicado: (2012)

Metabolism of Natural Killer Cells and Other Innate Lymphoid Cells
por: Cong, Jingjing
Publicado: (2020)

Screening for Hepatocellular Carcinoma in Patients with Hepatitis B
por: Sachar, Yashasavi, et al.
Publicado: (2021)

Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index
por: Li, Yulin, et al.
Publicado: (2019)

Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood
por: Hamilton, Carly A., et al.
Publicado: (2017)

Metabolic changes in cancer cells upon suppression of MYC
por: Anso, Elena, et al.
Publicado: (2013)

Human CD81 directly enhances T(h)1 and T(h)2 cell activation, but preferentially induces proliferation of T(h)2 cells upon long-term stimulation
por: Maecker, Holden T
Publicado: (2003)

Immune profiling of COVID-19: preliminary findings and implications for the pandemic
por: Maecker, Holden T
Publicado: (2021)

Functional Interactions between Retinoblastoma and c-MYC in a Mouse Model of Hepatocellular Carcinoma
por: Saddic, Louis A., et al.
Publicado: (2011)

Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults
por: Lingblom, Christine M. D., et al.
Publicado: (2018)

Modeling Human Natural Killer Cell Development in the Era of Innate Lymphoid Cells
por: Scoville, Steven D., et al.
Publicado: (2017)

Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis
por: Beer, Shelly, et al.
Publicado: (2008)

RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC
por: Selvarajan, V, et al.
Publicado: (2017)

Generation and validation of CRISPR-engineered human natural killer cell lines for research and therapeutic applications
por: Kumar, Anil, et al.
Publicado: (2021)

“Picolog,” a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo
por: DeChristopher, Brian A., et al.
Publicado: (2012)

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia
por: Kumar, Anil, et al.
Publicado: (2023)

Mechanisms of Innate Lymphoid Cell and Natural Killer T Cell Activation during Mucosal Inflammation
por: Nau, David, et al.
Publicado: (2014)

How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?
por: Huhn, Oisín, et al.
Publicado: (2021)

Normal Lymphocyte Development but Delayed Humoral Immune Response in CD81-null Mice
por: Maecker, Holden T., et al.
Publicado: (1997)

Immune monitoring technology primer: flow and mass cytometry
por: Maecker, Holden T., et al.
Publicado: (2015)

Socioeconomic Factors Contribute to the Higher Risk of COVID-19 in Racial and Ethnic Minorities With Chronic Liver Diseases
por: Adeniji, Nia, et al.
Publicado: (2021)

Critical B-lymphoid cell intrinsic role of endogenous MCL-1 in c-MYC-induced lymphomagenesis
por: Grabow, S, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u71h0ch3bnsdmcb9bbq1hpv5u4