Mutational bias and the protein code shape the evolution of splicing enhancers

Exonic splicing enhancers (ESEs) are enriched in exons relative to introns and bind splicing activators. This study considers a fundamental question of co-evolution: How did ESE motifs become enriched in exons prior to the evolution of ESE recognition? We hypothesize that the high exon to intron mot...

Descripción completa

Detalles Bibliográficos
Autores principales: Rong, Stephen, Buerer, Luke, Rhine, Christy L., Wang, Jing, Cygan, Kamil J., Fairbrother, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275064/
https://www.ncbi.nlm.nih.gov/pubmed/32504065
http://dx.doi.org/10.1038/s41467-020-16673-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275064/
https://www.ncbi.nlm.nih.gov/pubmed/32504065
http://dx.doi.org/10.1038/s41467-020-16673-z

Ejemplares similares