Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing

Fusion genes are hallmarks of various cancer types and important determinants for diagnosis, prognosis and treatment. Fusion gene partner choice and breakpoint-position promiscuity restricts diagnostic detection, even for known and recurrent configurations. Here, we develop FUDGE (FUsion Detection f...

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Detalles Bibliográficos
Autores principales: Stangl, Christina, de Blank, Sam, Renkens, Ivo, Westera, Liset, Verbeek, Tamara, Valle-Inclan, Jose Espejo, González, Rocio Chamorro, Henssen, Anton G., van Roosmalen, Markus J., Stam, Ronald W., Voest, Emile E., Kloosterman, Wigard P., van Haaften, Gijs, Monroe, Glen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275081/
https://www.ncbi.nlm.nih.gov/pubmed/32504042
http://dx.doi.org/10.1038/s41467-020-16641-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275081/
https://www.ncbi.nlm.nih.gov/pubmed/32504042
http://dx.doi.org/10.1038/s41467-020-16641-7

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