Transcriptional consequences of MBD5 disruption in mouse brain and CRISPR-derived neurons

BACKGROUND: MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome sequencing studies have directly implicated MBD5 in the etiology of autism spec...

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Detalles Bibliográficos
Autores principales: Seabra, Catarina M., Aneichyk, Tatsiana, Erdin, Serkan, Tai, Derek J. C., De Esch, Celine E. F., Razaz, Parisa, An, Yu, Manavalan, Poornima, Ragavendran, Ashok, Stortchevoi, Alexei, Abad, Clemer, Young, Juan I., Maciel, Patricia, Talkowski, Michael E., Gusella, James F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275313/
https://www.ncbi.nlm.nih.gov/pubmed/32503625
http://dx.doi.org/10.1186/s13229-020-00354-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275313/
https://www.ncbi.nlm.nih.gov/pubmed/32503625
http://dx.doi.org/10.1186/s13229-020-00354-1

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