Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania

BACKGROUND: Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one individual to another. Most research has focused on common gen...

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Detalles Bibliográficos
Autores principales: Nkya, Siana, Mwita, Liberata, Mgaya, Josephine, Kumburu, Happiness, van Zwetselaar, Marco, Menzel, Stephan, Mazandu, Gaston Kuzamunu, Sangeda, Raphael, Chimusa, Emile, Makani, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275552/
https://www.ncbi.nlm.nih.gov/pubmed/32503527
http://dx.doi.org/10.1186/s12881-020-01059-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275552/
https://www.ncbi.nlm.nih.gov/pubmed/32503527
http://dx.doi.org/10.1186/s12881-020-01059-1

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