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Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and IL-2. However, unlike Foxp3(+) naturally occurring Tregs, such in vitro induced Tregs (iTregs) are functionally unstable mainly because of inco...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275710/ https://www.ncbi.nlm.nih.gov/pubmed/32414925 http://dx.doi.org/10.1073/pnas.1922600117 |