Cargando…

Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and IL-2. However, unlike Foxp3(+) naturally occurring Tregs, such in vitro induced Tregs (iTregs) are functionally unstable mainly because of inco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mikami, Norihisa, Kawakami, Ryoji, Chen, Kelvin Y., Sugimoto, Atsushi, Ohkura, Naganari, Sakaguchi, Shimon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275710/ https://www.ncbi.nlm.nih.gov/pubmed/32414925 http://dx.doi.org/10.1073/pnas.1922600117

Ejemplares similares

Molecular Determinants of Regulatory T Cell Development: The Essential Roles of Epigenetic Changes
por: Kitagawa, Yohko, et al.
Publicado: (2013)

Brazilian green propolis promotes TNFR2 expression on regulatory T cells
por: Mikami, Norihisa, et al.
Publicado: (2021)

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
por: Ohkura, Naganari, et al.
Publicado: (2020)

VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
por: Yasumizu, Yoshiaki, et al.
Publicado: (2020)

Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells
por: Herppich, Susanne, et al.
Publicado: (2019)

Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective
por: Sakaguchi, Shimon, et al.
Publicado: (2023)

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells
por: Garg, Garima, et al.
Publicado: (2017)

Treating type-1 diabetes with an epigenetic drug
por: Kitagawa, Yohko, et al.
Publicado: (2014)

Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer
por: Minohara, Kiyoshi, et al.
Publicado: (2023)

Functional Roles of the IgM Fc Receptor in the Immune System
por: Kubagawa, Hiromi, et al.
Publicado: (2019)

Taking regulatory T cells into medicine
por: Sakaguchi, Shimon
Publicado: (2021)

Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro
por: Azevedo, Rita I., et al.
Publicado: (2020)

Regulatory T cells for the control of physiological and pathological immune responses
por: Sakaguchi, Shimon
Publicado: (2011)

Regulatory roles of IL-10–producing human follicular T cells
por: Cañete, Pablo F., et al.
Publicado: (2019)

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis
por: Morita, Takayoshi, et al.
Publicado: (2016)

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo
por: Satou, Yorifumi, et al.
Publicado: (2011)

Control of Immune Responses by Naturally Arising CD4(+) Regulatory T Cells That Express Toll-like Receptors
por: Sakaguchi, Shimon
Publicado: (2003)

Control of Germinal Center Responses by T-Follicular Regulatory Cells
por: Wing, James B., et al.
Publicado: (2018)

A paragon of self-tolerance: CD25(+)CD4(+ )regulatory T cells and the control of immune responses
por: Fehérvári, Zoltán, et al.
Publicado: (2004)

Identification of the novel FOXP3-dependent T(reg) cell transcription factor MEOX1 by high-dimensional analysis of human CD4(+) T cells
por: Baßler, Kevin, et al.
Publicado: (2023)

The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer
por: Haruna, Miya, et al.
Publicado: (2022)

Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy
por: Tay, Christopher, et al.
Publicado: (2020)

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
por: Yasuda, Keiko, et al.
Publicado: (2019)

Perovskite/CIGS Spectral Splitting Double Junction Solar Cell with 28% Power Conversion Efficiency
por: Nakamura, Motoshi, et al.
Publicado: (2020)

Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation
por: Kouakanou, Léonce, et al.
Publicado: (2020)

Protocol to evaluate cell lineage stability of mouse natural and induced regulatory T cells using bisulfite sequencing
por: Arai, Masaya, et al.
Publicado: (2022)

HTLV-1 bZIP factor-mediated dysfunction of regulatory T cells in vivo
por: Miyazato, Paola, et al.
Publicado: (2011)

Tumor-associated macrophages promote intratumoral conversion of conventional CD4(+) T cells into regulatory T cells via PD-1 signalling
por: Kos, Kevin, et al.
Publicado: (2022)

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
por: Yasumizu, Yoshiaki, et al.
Publicado: (2022)

Tumour grade significantly correlates with total dysfunction of tumour tissue-infiltrating lymphocytes in renal cell carcinoma
por: Kawashima, Atsunari, et al.
Publicado: (2020)

Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance
por: Yamaguchi, Tomoyuki, et al.
Publicado: (2019)

CD28(−) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men
por: Vuddamalay, Yirajen, et al.
Publicado: (2017)

Homeostatic maintenance of natural Foxp3 (+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
por: Setoguchi, Ruka, et al.
Publicado: (2005)

S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
por: Nagira, Yoji, et al.
Publicado: (2023)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Epigenetic Memory: Lessons From iPS Cells Derived From Human β Cells
por: Efrat, Shimon
Publicado: (2021)

TCR signaling by conventional CD4(+) T cells is required for optimal maintenance of peripheral regulatory T cell numbers
por: Leichner, Theresa M., et al.
Publicado: (2016)

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy
por: Peeters, J.G.C., et al.
Publicado: (2018)

Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells
por: Dilek, Nahzli, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mcql88p3kiavtmsgqnpm307vn5